12 Mai 2018

Serious neuropsychiatric symptoms have been reported in patients taking bupropion for smoking cessation see boxed warning, adverse reactions .

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the average daily infant exposure assuming 150 ml kg daily consumption to bupropion and its active metabolites was 2 of the maternal weight-adjusted dose.

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you can start taking bupropion 1-2 weeks before your quit date.

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the effects of age on the pharmacokinetics of bupropion and its metabolites have not been fully characterized, but an exploration of steady-state bupropion concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg day, on a 3 times daily schedule, revealed no relationship between age 18 to 83 years and plasma concentration of bupropion.

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therefore, direct actions of cocaine and bupropion on the da transporter might underlie their neuroadaptive effects on that protein.

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the c max and auc values of hydroxybupropion are approximately 3 and 14 times higher, respectively, than bupropion c max and auc values.
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