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Be careful with moduretic if you take potassium-sparing diuretics eg, spironolactone , potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease moduretic s effectiveness; nonsteroidal anti-inflammatory drugs nsaids eg, indomethacin because they may decrease moduretic s effectiveness and risk of kidney problems may be increased; barbiturates eg, phenobarbital , certain chemotherapy medicines, corticosteroids eg, prednisone , digoxin, dofetilide, ketanserin, narcotic pain medicines eg, codeine , or medicines for high blood pressure because the risk of their side effects may be increased by moduretic; diazoxide, lithium, or nondepolarizing neuromuscular blockers eg, pancuronium because their actions and the risk of their side effects may be increased by moduretic; angiotensin-converting enzyme ace inhibitors eg, enalapril because the risk of high blood potassium and kidney problems may be increased by moduretic; diabetes medicines eg, glipizide or insulin because their effectiveness may be decreased by moduretic.

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